Hi Dr. Z, have you ever synthesized any ibogaine analogues (besides noribogaine)? I’m hoping some Neoshulginist such as yourself will be able to create such an analogue that can be used safely in residential treatment settings for opioid detoxification and to kickstart the process of Recovery from addictions.
Ideal pharmacological activities to retain from ibogaine: - 5HT2A agonist
- NMDA antagonist
- kappa opioid agonist
- alpha3, beta4 nAchR antagonist
Obviously the properties to avoid are effects on ion channels to avoid ibogaine’s arrhythmia-inducing, QTc prolongation, and cerebellar toxicity effects (ataxia, intention tremor).
Addiction Psychiatrist in California, and former friend of Sasha’s (who I named my daughter after)