Hi Dr. Z, have you ever synthesized any ibogaine analogues (besides noribogaine)? I’m hoping some Neoshulginist such as yourself will be able to create such an analogue that can be used safely in residential treatment settings for opioid detoxification and to kickstart the process of Recovery from addictions.
Ideal pharmacological activities to retain from ibogaine: - 5HT2A agonist
- NMDA antagonist
- kappa opioid agonist
- alpha3, beta4 nAchR antagonist
Obviously the properties to avoid are effects on ion channels to avoid ibogaine’s arrhythmia-inducing, QTc prolongation, and cerebellar toxicity effects (ataxia, intention tremor).
Peace,
Nick
Addiction Psychiatrist in California, and former friend of Sasha’s (who I named my daughter after)
I read that the ibogaine structure is so complex that it could be difficult to synthesize at the current time. It is a very unique tryptamine.
Dear Nick, thank you for your enquiry
You can see in the attached screenshots from Mind Medicine in the 4th row that 18-mc which is an Ibogaine analog is now in Phase 2a of their research.
I sold one of my drug assisted psycho-therapy patents to Mind Medicine a year ago and am in close contact with the company.
I feel they would value your enquiry and would be happy to forward it with your permission